When attempting to detect the earliest volume loss related to brain atrophy, however, visual inspection alone lacks sensitivity compared with automated methods. The current clinical standard of care in neuroradiology involves visual inspection of brain MRI. 4 Because all of these disorders can present with cognitive impairment, the ability to apply improved diagnostic tools is crucial for patient care. 3 TBI increases the risk for later dementia and chronic traumatic encephalopathy (CTE). 1,2 Traumatic brain injury (TBI) is also a common problem affecting 2.5 million persons annually. Collectively, these conditions affect almost 6 million persons in the US alone. Among the most common are Alzheimer disease (AD) dementia and frontotemporal dementia (FTD), respectively the first and second most common neurodegenerative causes of dementia worldwide. Neurocognitive disorders are prevalent clinical problems.
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